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FLASH GENE

Symbol

HOXA11

contributors: mct - updated : 02-02-2011

HGNC name	homeobox A11
HGNC id	5101

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	homeobox gene A cluster
STRUCTURE	4.06 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

motif	repetitive sequence
text structure	polyalamine stretch in exon 1

MAPPING

cloned

Y

linked

N

status

confirmed

Map

see HOXA@

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005523 2 - 2653 NP_005514 - 313 - 2009 19727442

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   moderately Reproductive female system uterus cervix   predominantly   female system placenta     highly   male system prostate     highly Respiratory lung         Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone subchondral   highly Epithelial barrier/lining endometrium

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text	placenta, expressed in the embryonic paramesonephric (Müllerian) ducts

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an homeobox DNA binding domain
	helix-turn-helix

HOMOLOGY

interspecies	homolog to murine Hoxa11 (98.1 pc)
	homolog to zebrafish hoxa11b (76 pc)

Homologene

FAMILY

ABD-B homeobox family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	involved in the regulation of uterine development
	required for female fertility
	playing a role in the developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis
	essential for organogenesis of the uterosacral ligaments
	required for prolactin expression in decidualized endometrial stromal cells

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development

text	morphogenesis

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein

physical association of HOXA11 and FOXO1, and binding of both factors to an enhancer region of the decidual prolactin promoter

cell & other

REGULATION

inhibited by

YY1 via direct physical interaction

Other

spatially and temporally regulated during embryonic development

ASSOCIATED DISORDERS

corresponding disease(s)

RUSAT

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion translocation     fused with NUP98 in t(7;11) (p15;p15) in chronic myeloid leukemia (in acute leukemia phase) constitutional     --low   with both collagens (collagen type I, collagen type III) was dramatically decreased in women with pelvic organ prolapse tumoral     --other   its DNA methylation was independently associated with poor outcome in ovarian cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS