| Symbol
| HOXA10
| contributors: mct - updated : 15-06-2016
|
| HGNC name
| homeobox A10
|
| HGNC id
| 5100
|
| corresponding disease(s)
|
HOXA10
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| constitutional
|
|
| --low
|
| |
in polycystic ovary syndrome (PCOS), contributing to the diminished reproduction potential of women | | tumoral
|
|
| --over
|
|
promoter hypomethylation is an important mechanism for high expression of HOXA10 in ovarian cancer and may be a potential prognostic factor in ovarian cancer  | | tumoral
|
|
| --over
|
| |
in poor prognosis human AML(acute myeloid leukemia), and HOXA10 overexpression in myeloid progenitor cells increased TGFB2 production by the cells | | tumoral
|
|
| --over
|
| |
of HOXA9 and HOXA10 and their essential cofactor MEIS1 in cells with the t(4;11) chromosome translocation and MLL-AF4 in acute leukemia | | tumoral
|
|
| --over
|
| |
increases FGF2 mRNA expression and FGF2 protein secretion in U937 myeloid leukemia cells | | tumoral
|
|
| --over
|
| |
in prostate cancer cell lines and tissues compared to those in normal prostate epithelium | |
| Susceptibility
|
to genital malformations |
| Variant & Polymorphism
other
| rare DNA sequence variations in the HOXA10 gene could contribute to the misdevelopment of female internal genitalia |
| 
|
| Candidate gene
| DNA methylation markers of Gastric cancer (GC), which may serve as useful markers that may identify a distinct subset of GC |
Marker
Therapy target
|
| | |
|
| mice with Hoxa10 gene disruption exhibited an overwhelming and fatal emergency granulopoiesis response that was characterized by tissue infiltration with granulocytes, but reversed by re-expression of Triad1 in the bone marrow |