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FLASH GENE
Symbol HOXA4 contributors: - updated : 03-02-2007
HGNC name homeo box A4
HGNC id 5105
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
helix-turn-helix, DNA binding domain
HOMOLOGY
interspecies homolog to murine Hox-1.4
homolog to Drosophila Dfd
Homologene
FAMILY ANTP homeobox family, deformed subfamily
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • involved in a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to hypospadias
    • Variant & Polymorphism other
  • polymorphism increasing the risk of hypospadias
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS