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FLASH GENE

Symbol

HOXA4

contributors: - updated : 03-02-2007

HGNC name	homeo box A4
HGNC id	5105

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly Nervous brain         Reproductive male system testis     highly Respiratory lung         Urinary kidney       highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, fetal, pregnancy

Text	pregnant uterus, heart, nervous system

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

helix-turn-helix, DNA binding domain

HOMOLOGY

interspecies	homolog to murine Hox-1.4
	homolog to Drosophila Dfd

Homologene

FAMILY

ANTP homeobox family, deformed subfamily

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

involved in a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to hypospadias

Variant & Polymorphism other	polymorphism increasing the risk of hypospadias

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS