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FLASH GENE
Symbol HOXA7 contributors: mct - updated : 17-04-2016
HGNC name homeo box A7
HGNC id 5108
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
helix-turn-helix,DNA binding domain followed by an alanine-rich region and a strongly negatively charged domain,consisting entirely of Asp and Glu residues
HOMOLOGY
interspecies homolog to murine Hox-1.1
homolog to Drosophila Antp,Ubx,abd-A
intraspecies homolog to HOXB7
Homologene
FAMILY ANTP family of homeoboxproteins
CATEGORY DNA associated , transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • RNA polymerase 2 transcription factor,silencing differentiation-specific genes during keratinocyte proliferation(regulaton of keratinocytes TGM1)
  • polyADP-ribosylation regulates transcriptional activities of HOX proteins such as HOXB7 and HOXA7
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MEIS1,HOXA9,coactivation in acute myeloid leukemia
    • HOXA5 and HOXAB7
  • role for HOXA7 in modulating breast cancer cell proliferation via regulation of ESR1 expression
  • HOXA7 stimulates human hepatocellular carcinoma proliferation through CCNE1/CDK2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in the Prostate carcinoma compared to the benign prostatic hyperplasia (BPH)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS