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FLASH GENE
Symbol HOXA7 contributors: mct - updated : 17-04-2016
HGNC name homeo box A7
HGNC id 5108
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines erythroleukemic cell line,epithelial ovarian tumor cell line with aberrant mullerian-like phenotype
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
helix-turn-helix,DNA binding domain followed by an alanine-rich region and a strongly negatively charged domain,consisting entirely of Asp and Glu residues
HOMOLOGY
interspecies homolog to murine Hox-1.1
homolog to Drosophila Antp,Ubx,abd-A
intraspecies homolog to HOXB7
Homologene
FAMILY ANTP family of homeoboxproteins
CATEGORY DNA associated , transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • RNA polymerase 2 transcription factor,silencing differentiation-specific genes during keratinocyte proliferation(regulaton of keratinocytes TGM1)
  • polyADP-ribosylation regulates transcriptional activities of HOX proteins such as HOXB7 and HOXA7
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MEIS1,HOXA9,coactivation in acute myeloid leukemia
    • HOXA5 and HOXAB7
  • role for HOXA7 in modulating breast cancer cell proliferation via regulation of ESR1 expression
  • HOXA7 stimulates human hepatocellular carcinoma proliferation through CCNE1/CDK2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in the Prostate carcinoma compared to the benign prostatic hyperplasia (BPH)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS