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FLASH GENE

Symbol

HOXA7

contributors: mct - updated : 17-04-2016

HGNC name	homeo box A7
HGNC id	5108

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	1.00 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

Map

see HOXA@

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument keratinocyte

cell lineage
cell lines	erythroleukemic cell line,epithelial ovarian tumor cell line with aberrant mullerian-like phenotype
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

helix-turn-helix,DNA binding domain followed by an alanine-rich region and a strongly negatively charged domain,consisting entirely of Asp and Glu residues

HOMOLOGY

interspecies	homolog to murine Hox-1.1
	homolog to Drosophila Antp,Ubx,abd-A

intraspecies

homolog to HOXB7

Homologene

FAMILY

ANTP family of homeoboxproteins

CATEGORY

DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	RNA polymerase 2 transcription factor,silencing differentiation-specific genes during keratinocyte proliferation(regulaton of keratinocytes TGM1)
	polyADP-ribosylation regulates transcriptional activities of HOX proteins such as HOXB7 and HOXA7

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	MEIS1,HOXA9,coactivation in acute myeloid leukemia
	HOXA5 and HOXAB7
	role for HOXA7 in modulating breast cancer cell proliferation via regulation of ESR1 expression
	HOXA7 stimulates human hepatocellular carcinoma proliferation through CCNE1/CDK2

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in the Prostate carcinoma compared to the benign prostatic hyperplasia (BPH)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS