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FLASH GENE

Symbol

EGR3

contributors: mct/pgu - updated : 09-04-2013

HGNC name	early growth response 3
HGNC id	3240

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	sensory ataxia and muscle spindle (encapsulated muscle fibers conservated by specialized motor and sensory axons) agenesis,suggesting that type I myotubes are dependent upon Egr3 mediated transcription for proper spindle development
	germline Egr3-deficient mice have physiologic dysautonomia characterized by apoptotic sympathetic neuron death and abnormal innervation to many target tissues