| Symbol
| MSR1
| contributors: mct/npt/pgu - updated : 11-04-2015
|
| HGNC name
| macrophage scavenger receptor 1
|
| HGNC id
| 7376
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
|
| loss of function
| |
by somatic mutations in rare prostatic cancer | | tumoral
| germinal mutation
|
|
|
| |
in prostate cancer family | | tumoral
|
|
| --over
|
| |
in breast carcinoma and in in colon cancer with long survival | | constitutional
|
|
| --over
|
|
spontaneous MSR1 expression of alveolar macrophages was significantly increased in patients with idiopathic pulmonary fibrosis (IPF)  | |
| Susceptibility
|
to prostate cancer to atherosclerosis |
| Variant & Polymorphism
SNP
, other
| major haplotype G-A-C-G-C-G combining five SNPs within MSR1 shown to increase prostate cancer risk significantly |
|
association between MSR1 polymorphisms and atherosclerosis |
| 
|
Candidate gene
Marker
Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| immunology | inflammatory | | |
| regulating the MSR1 activity will likely be an effective therapeutic tool to regulate various inflammatory diseases such as septic shock | | neurology | neurodegenerative | alzheimer | |
| targeting MSR1 for future diagnostic and therapeutic approaches for cerebral amyloid angiopathy | | cancer | hemopathy | | |
| enhancement of the tumor suppressor function of MSR1 may be of significance in the development of novel therapeutic strategies for chronic myeloid leukemia |
| | | |
|
| Msr1-deficient mice had elevated serum concentrations of glucose-6-phosphate isomerase |