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FLASH GENE

Symbol

MSR1

contributors: mct/npt/pgu - updated : 11-04-2015

HGNC name	macrophage scavenger receptor 1
HGNC id	7376

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_138715 10 - 3761 NP_619729 - 451 - 2009 19911804 also called phSRA1 functional NM_002445 9 - 2960 NP_002436 39.5 358 - 2009 19911804 also called phSRA2 functional NM_138716 9 - 3572 NP_619730 34 308 - 2009 19911804 also called phSRA3 trapped in ER, not functional potential inhibitor of isoforms 1 and 2

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine adrenal gland       highly   pancreas         Lymphoid/Immune spleen       highly Nervous brain         Homo sapiens Respiratory lung       highly Urinary kidney       highly

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune macrophage Homo sapiens Nervous astrocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one cytoplasmic domain (N terminal)
	one transmembrane protein (TM1) with an extracellular cysteine-rich domain (SRCR,group A) and a collagen triple helix repeat (20 copies)
	extracellular collagenous domain can bind not only LPS but also various negatively-charged macromolecules such as modified low-density lipoprotein

conjugated

FlavoP , GlycoP

mono polymer

homomer , trimer

HOMOLOGY

interspecies

homolog to murine Msr1

Homologene

FAMILY

scavenger receptor A family

CATEGORY

receptor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic,vesicle
text	type II trimeric transmembrane glycoprotein

basic FUNCTION	oxidized low density lipoprotein receptor
	involved in the pathologic deposition of cholesterol in arterial walls during atherogenesis
	multifunctional, multiligand pattern recognition receptor with roles in innate immunity, apoptotic cell clearance, and age-related degenerative pathologies
	mediates the uptake of modified low density lipoprotein (LDL)-cholesterol
	suppresses leukemia stem cells (LSCs) and CML (chronic myeloid leukemia) development
	suppresses the macrophage activation by inhibiting the binding of LPS (lipopolysaccharide) to TLR4 in a competitive manner and it plays a pivotal role in the regulation of the LPS-induced inflammatory response
	suppresses LPS-induced macrophage activation by competitive binding LPS to reduce TLR4 signaling
	CD36 and MSR1 involved in the development and/or progression of Acute Coronary Syndromes (ACS)
	important role in cerebrovascular amyloid pathology
	enhancement of MSR1 via inhibition of PPARG appears to be the most likely basis of sustained ox-LDL uptake in the absence or presence of OLR1
	participate in the maintenance of immunological tolerance
	influences B cell autoimmunity by regulating soluble autoantigen concentration
	participates in the regulation of inflammatory processes against pathogens and in inflammatory stimulation
	participates likely in the modulation of signaling pathways involved in the production of soluble molecules implicated in the neuroinflammatory response
	multifunctional molecule that participates in macrophage-mediated inflammation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense , endocytosis transport

PATHWAY

metabolism

lipid/lipoprotein

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	with SCARF1 and SCARB1 are receptors for UMOD
	recognize the exchangeable apolipoproteins AI and E (apo AI and apo E, respectively) in both lipid-free and lipid-associated form
	OLR1 stimulates PPARG and subsequently enhances CD36 and inhibits MSR1 in macrophages
	is required for LPS-induced TLR4 mediated NFKB1 activation in macrophages
	is critical for AGT-induced vascular remodeling by regulating macrophage polarization

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       loss of function by somatic mutations in rare prostatic cancer tumoral germinal mutation       in prostate cancer family tumoral     --over   in breast carcinoma and in in colon cancer with long survival constitutional     --over   spontaneous MSR1 expression of alveolar macrophages was significantly increased in patients with idiopathic pulmonary fibrosis (IPF)

Susceptibility

to prostate cancer to atherosclerosis

Variant & Polymorphism SNP , other	major haplotype G-A-C-G-C-G combining five SNPs within MSR1 shown to increase prostate cancer risk significantly
	association between MSR1 polymorphisms and atherosclerosis

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed immunology inflammatory   regulating the MSR1 activity will likely be an effective therapeutic tool to regulate various inflammatory diseases such as septic shock neurology neurodegenerative alzheimer targeting MSR1 for future diagnostic and therapeutic approaches for cerebral amyloid angiopathy cancer hemopathy   enhancement of the tumor suppressor function of MSR1 may be of significance in the development of novel therapeutic strategies for chronic myeloid leukemia

ANIMAL & CELL MODELS

Msr1-deficient mice had elevated serum concentrations of glucose-6-phosphate isomerase