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FLASH GENE
Symbol MYL2 contributors: mct - updated : 11-03-2011
HGNC name myosin, light polypeptide 2, regulatory, cardiac, slow
HGNC id 7583
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumcardiac  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an EF-hand Ca2+–Mg2+ binding site and also a highly conserved phosphorylatable serine, both sites located at the N terminus
  • three EF-hand calcium-binding domain
    • secondary structure two heavy chains and four light chains
    mono polymer hexamer
    HOMOLOGY
    interspecies homolog to murine Mylpc
    Homologene
    FAMILY
    CATEGORY motor/contractile , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • regulatory light chain associated with cardiac myosin beta (or slow) heavy chain, playing a role in in the regulation of cardiac muscle contraction
  • required for thick-filament stabilization and contractility in the vertebrate heart
  • regulatory component of myosin heavy polypeptide, that may play a role in the development and progression of chronic heart failure
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cardiovascular , locomotion
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein EF hand calcium binding protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CMH10
    related resource FHC Mutation Database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in heart failure tissue
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS