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FLASH GENE

Symbol

MYL2

contributors: mct - updated : 11-03-2011

HGNC name	myosin, light polypeptide 2, regulatory, cardiac, slow
HGNC id	7583

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000432 7 - 855 - 166 - 2006 16809551

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum cardiac

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an EF-hand Ca2+–Mg2+ binding site and also a highly conserved phosphorylatable serine, both sites located at the N terminus
	three EF-hand calcium-binding domain

secondary structure

two heavy chains and four light chains

mono polymer

hexamer

HOMOLOGY

interspecies

homolog to murine Mylpc

Homologene

FAMILY

CATEGORY

motor/contractile , structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton

basic FUNCTION	regulatory light chain associated with cardiac myosin beta (or slow) heavy chain, playing a role in in the regulation of cardiac muscle contraction
	required for thick-filament stabilization and contractility in the vertebrate heart
	regulatory component of myosin heavy polypeptide, that may play a role in the development and progression of chronic heart failure

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cardiovascular , locomotion

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

EF hand calcium binding protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CMH10

related resource

FHC Mutation Database

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in heart failure tissue

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS