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FLASH GENE
Symbol MYL2 contributors: mct - updated : 11-03-2011
HGNC name myosin, light polypeptide 2, regulatory, cardiac, slow
HGNC id 7583
DNA
TYPE functioning gene
STRUCTURE 9.78 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 855 - 166 - 2006 16809551
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumcardiac  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an EF-hand Ca2+–Mg2+ binding site and also a highly conserved phosphorylatable serine, both sites located at the N terminus
  • three EF-hand calcium-binding domain
    • secondary structure two heavy chains and four light chains
    mono polymer hexamer
    HOMOLOGY
    interspecies homolog to murine Mylpc
    Homologene
    FAMILY
    CATEGORY motor/contractile , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • regulatory light chain associated with cardiac myosin beta (or slow) heavy chain, playing a role in in the regulation of cardiac muscle contraction
  • required for thick-filament stabilization and contractility in the vertebrate heart
  • regulatory component of myosin heavy polypeptide, that may play a role in the development and progression of chronic heart failure
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cardiovascular , locomotion
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein EF hand calcium binding protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CMH10
    related resource FHC Mutation Database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in heart failure tissue
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS