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FLASH GENE

Symbol

TYRP1

contributors: mct/npt - updated : 07-10-2017

HGNC name	tyrosinase-related protein 1
HGNC id	12450

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

OCA3

related resource

Albinism Database

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --other   melanocytes in vitiligo have reduced ability to withstand oxidative stress due, partly, to a disruption in MITF regulation of TYRP1

Susceptibility

to cutaneous melanoma (CM)

Variant & Polymorphism other	haplotype increasing the risk of cutaneous melanoma (CM)

Candidate gene
Marker	prognostic marker for melanoma, and is particularly useful when prognostic pathology parameters at the primary lesion are lacking
Therapy target
	System Type Disorder Pubmed cancer skin   its conserved expression further supports TYRP1 use as a target for therapy cancer eye   potential use of TYRP1 in the development of therapy for Uveal melanoma (UM)

ANIMAL & CELL MODELS