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FLASH GENE

Symbol

TNC

contributors: mct - updated : 06-02-2015

HGNC name	tenascin C
HGNC id	5318

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

DFNA56

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast cancer cells,in astrocytoma and glioma in progression tumoral     --other   expression in pilocytic and diffuse astrocytomas constitutional     --over   in scleroderma (SSc), scleroderma spectrum disorder (SSD), and localized scleroderma (LSc)

Susceptibility

to asthma and rhinoconjunctivitis

Variant & Polymorphism other	polymorphisms might play a more independent role for development of upper airway disease such as rhinoconjunctivitis, whereas for asthma, the interplay with other genes, like NPSR1, becomes more prominent

Candidate gene
Marker	aberrant expression of NNAT and TNC was a useful marker for distinguishing malignant peripheral nerve sheath tumor (MPNST) from benign neurofibroma
	FBN2, TNC, MATN2, and MATN4 may be markers of the pathogenesis of either granular or lattice type I corneal dystrophy
	realistic and promising biomarker and a target for molecular imaging for the diagnosis of various cardiovascular diseases
Therapy target
	System Type Disorder Pubmed neurology neurodegenerative alzheimer potential for TNC as a new therapeutic target in AD cardiovascular aquired   therapeutic target as a key molecule in the control of the balance of beneficial and undesirable cellular responses during tissue remodeling

ANIMAL & CELL MODELS