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FLASH GENE
Symbol TNC contributors: mct - updated : 06-02-2015
HGNC name tenascin C
HGNC id 5318
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 15 EGF-like domains
  • 15 fibronectin type III domains (3th to 5th are heparin-binding site)
  • a fibrinogen-like globe domain, a 227–AA(26.9 kDa) globular domain at the C-terminus
    • conjugated GlycoP
    mono polymer homomer , hexamer
    HOMOLOGY
    interspecies homolog to murine Tnc
    Homologene
    FAMILY
  • tenascin family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    text
  • mesenchymal extracellular matrix
  • extracellular matrix brain glycoprotein
  • present in the basilar membrane (BM), and the osseous spiral lamina of the cochlea
    • basic FUNCTION
  • substrate adhesion molecule of the extra-cellular matrix
  • promoting neurite outgrowth of embryonic hippocampal neurons through the alternatively spliced fibronectin type III BD domains via activation of the cell adhesion molecule
  • like TNC, FBLN1 inhibits fibroblast spreading and cell-mediated contraction of a fibrin-FN matrix
  • TNC and TNR play antagonistic roles for differentiation and comparably inhibit morphologic maturation
  • endogenous activator of TLR4-mediated immunity that mediates persistent synovial inflammation and tissue destruction in arthritic joint disease
  • playing a potential role in the pathogenesis of rheumatoid arthritis, where its induction upon tissue injury creates a perpetual destructive cycle
  • role of tenascin-C as a regulator of the fibrinolytic system
  • potential role for this protein in vascular morphogenesis, in matrices of injured and tumor tissues
  • is a critical component of the bone marrow microenvironment that is required for hematopoietic regeneration
  • matricellular protein expressed during embryonic development, as well as in wound healing and cancer invasion in various tissues, and may regulate cell behavior and matrix organization during tissue remodeling
  • TNC and tenascin-R (TNR) play important roles in cell proliferation and migration, fate determination, axonal pathfinding, myelination, and synaptic plasticity
  • in cell interactions during development and, in the adult, in synaptic activity and plasticity, as well as regeneration after injury, TNC is conducive for regeneration and TNR is inhibitory for functional recovery
  • plays an important role in cochlear development
  • unidentified roles for TNC in hemopoiesis: in lineage commitment of thymic T cell progenitors, peripheral T cell migration, and hemopoietic reconstitution
  • TNC and tenascin-R (TNR), regulate differentiation and migration, in addition to neurite outgrowth and survival in numerous types of neurons and mesenchymal progenitor cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • hexamer of the monomers tenascin C or brachion, associated with active epithelial-stromal interactions
    • contactin
  • a homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CTSB in the progression of gliomas
  • induced by mutated BMP type II receptors in familial forms of pulmonary arterial hypertension
  • interacting with NT5E (a novel and specific receptor for tenascin C and the interaction between these proteins may influence cell adhesion and migration and also lead to decreased generation of local adenosine)
  • TNC and TNR interfered with the activation of the small GTPase RHOA
  • stromal TNC, predominantly provided by S100A4+ cells, facilitates metastatic colonization
  • downregulates DKK1 promoter activity through the blocking of actin stress fiber formation, activates WNT signaling, and induces WNT target genes in tumor and endothelial cells
    • cell & other
    REGULATION
    induced by tumor-specific EWSR1-ETS1 fusion gene
    TGFB
    repressed by regulated by FLI1in the development of neural crest cells
    GATA6 (transcriptional repressor of TNC gene expression in fibroblasts
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNA56
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer cells,in astrocytoma and glioma in progression
    tumoral     --other  
    expression in pilocytic and diffuse astrocytomas
    constitutional     --over  
    in scleroderma (SSc), scleroderma spectrum disorder (SSD), and localized scleroderma (LSc)
    Susceptibility to asthma and rhinoconjunctivitis
    Variant & Polymorphism other polymorphisms might play a more independent role for development of upper airway disease such as rhinoconjunctivitis, whereas for asthma, the interplay with other genes, like NPSR1, becomes more prominent
    Candidate gene
    Marker
  • aberrant expression of NNAT and TNC was a useful marker for distinguishing malignant peripheral nerve sheath tumor (MPNST) from benign neurofibroma
  • FBN2, TNC, MATN2, and MATN4 may be markers of the pathogenesis of either granular or lattice type I corneal dystrophy
  • realistic and promising biomarker and a target for molecular imaging for the diagnosis of various cardiovascular diseases
    • Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerativealzheimer
    potential for TNC as a new therapeutic target in AD
    cardiovascularaquired 
    therapeutic target as a key molecule in the control of the balance of beneficial and undesirable cellular responses during tissue remodeling
    ANIMAL & CELL MODELS