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FLASH GENE
Symbol ITGA5 contributors: mct - updated : 20-05-2014
HGNC name integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
HGNC id 6141
Location 12q11-q13      Physical location : 54.789.046 - 54.813.050
Synonym name
  • cell differentiation antigen CD49E
  • very late activation protein 5, alpha subunit
  • Synonym symbol(s) CD49E, FNRA, VLA5A
    DNA
    TYPE functioning gene
    STRUCTURE 24.00 kb     30 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
     thymus   highly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal large extracellular domain
  • a sevenfold repeated structure (7 FG-GAP repeats) with putative cation-binding motifs in the three of four C terminal repeats, proteolytically processed into disulfide linked heavy and light chains
  • The extracellular domain is connected by a single transmembrane segment (1TM) to a short conserved cytoplasmic domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY integrin alpha chain family
    CATEGORY adhesion , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
  • recognizes the sequence R-G-D in its ligands
  • FN1 and ITGA5 play requisite roles in cardiac morphogenesis
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • an alpha chain and a beta chain
  • alpha 5 constituent of VLA-5 receptor
  • complexing with ITGB1 in fibronectin receptor
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by DIDO1, inducing the expression of ITGA5, thereby promoting the attachment, migration, invasion and apoptosis resistance of melanoma cells
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS