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FLASH GENE

Symbol

PRSS1

contributors: mct/npt - updated : 26-08-2009

HGNC name	protease, serine, 1 (trypsin 1)
HGNC id	9475

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

HPG

related resource

Database of genetic variants in patients

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional fusion     gain of function PRSS1/PRSS2, exons 1 and 2 are derived from PRSS2 and exons 3-5 from PRSS1, apparently resulted from a non-allelic homologous recombination, with double gain-of-function effect in chronic pancreatitis

Susceptibility

to chronic pancreatitis, to pancreatic cancer

Variant & Polymorphism other	mutation loss of function protecting against pancreatitis

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS