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FLASH GENE
Symbol PRSS1 contributors: mct/npt - updated : 26-08-2009
HGNC name protease, serine, 1 (trypsin 1)
HGNC id 9475
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Endocrinepancreas   highly
Lymphoid/Immunethymus   highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text pancreas
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 15 AA signal
  • 8 AA activation sites
    • HOMOLOGY
    interspecies homolog to murine Try1
    Homologene
    FAMILY
  • peptidase family S1 (trypsin family)
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • protease serine, cationic trypsinogen, playing a role in peptide linkages involving the carboxyl group of lysine or arginine
  • playing a role in the digestion
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS digestion
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PRSS2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HPG
    related resource Database of genetic variants in patients
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional fusion     gain of function
    PRSS1/PRSS2, exons 1 and 2 are derived from PRSS2 and exons 3-5 from PRSS1, apparently resulted from a non-allelic homologous recombination, with double gain-of-function effect in chronic pancreatitis
    Susceptibility to chronic pancreatitis, to pancreatic cancer
    Variant & Polymorphism other mutation loss of function protecting against pancreatitis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS