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FLASH GENE

Symbol

PRSS1

contributors: mct/npt - updated : 26-08-2009

HGNC name	protease, serine, 1 (trypsin 1)
HGNC id	9475

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	3.61 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map

see TCRB

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002769 5 - 821 NP_002760 - 247 - Yamamoto (1992)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Endocrine pancreas       highly Lymphoid/Immune thymus       highly Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

pancreas

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	15 AA signal
	8 AA activation sites

HOMOLOGY

interspecies

homolog to murine Try1

Homologene

FAMILY

peptidase family S1 (trypsin family)

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	protease serine, cationic trypsinogen, playing a role in peptide linkages involving the carboxyl group of lysine or arginine
	playing a role in the digestion

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

digestion

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

PRSS2

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

HPG

related resource

Database of genetic variants in patients

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional fusion     gain of function PRSS1/PRSS2, exons 1 and 2 are derived from PRSS2 and exons 3-5 from PRSS1, apparently resulted from a non-allelic homologous recombination, with double gain-of-function effect in chronic pancreatitis

Susceptibility

to chronic pancreatitis, to pancreatic cancer

Variant & Polymorphism other	mutation loss of function protecting against pancreatitis

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS