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FLASH GENE
Symbol TG contributors: SGE/npt - updated : 19-06-2009
HGNC name thyroglobulin
HGNC id 11764
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a carboxy-terminal cholinesterase like (ChEL) domain, critically important in TG export from the endoplasmic reticulum
  • 11 tyroglobulin type 1 repeats
    • conjugated GlycoP
    mono polymer homomer , dimer
    isoforms Precursor precursor of thyroid hormone
    HOMOLOGY
    interspecies homolog to murine Tg (74.3pc)
    homolog to rattus Tg (73.5pc)
    Homologene
    FAMILY
  • type B carboxylase/lipase family
    • CATEGORY storage , signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
    text secreted protein
    basic FUNCTION
  • involved in storage of iodine and of inactive thyroid hormones
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism hormone
    signaling hormonal , signal transduction
  • cell to cell signaling
  • hormone biosynthetic process
    • a component forming homodimers through the ChEL domains (Lee 2009)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TG
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    mRNA levels are higher in subjects with thyroid disease (Amakawa 2008)
    Susceptibility
  • to autoimmune thyroid disease
    • Variant & Polymorphism
  • thyroid hormone synthesis is inhibited because of mutations in the ChEL domain that block protein export from the ER (Lee 2009)
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS