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FLASH GENE
Symbol TG contributors: SGE/npt - updated : 19-06-2009
HGNC name thyroglobulin
HGNC id 11764
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunelymphocyte
cell lineage
cell lines expressed on follicular dendritic cells of thyroid mucosa-associated lymphoid tissue (MALT) lymphoma (Munemasa 2009)
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a carboxy-terminal cholinesterase like (ChEL) domain, critically important in TG export from the endoplasmic reticulum
  • 11 tyroglobulin type 1 repeats
    • conjugated GlycoP
    mono polymer homomer , dimer
    isoforms Precursor precursor of thyroid hormone
    HOMOLOGY
    interspecies homolog to murine Tg (74.3pc)
    homolog to rattus Tg (73.5pc)
    Homologene
    FAMILY
  • type B carboxylase/lipase family
    • CATEGORY storage , signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
    text secreted protein
    basic FUNCTION
  • involved in storage of iodine and of inactive thyroid hormones
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism hormone
    signaling hormonal , signal transduction
  • cell to cell signaling
  • hormone biosynthetic process
    • a component forming homodimers through the ChEL domains (Lee 2009)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TG
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    mRNA levels are higher in subjects with thyroid disease (Amakawa 2008)
    Susceptibility
  • to autoimmune thyroid disease
    • Variant & Polymorphism
  • thyroid hormone synthesis is inhibited because of mutations in the ChEL domain that block protein export from the ER (Lee 2009)
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS