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FLASH GENE
Symbol RLN2 contributors: mct - updated : 29-11-2014
HGNC name relaxin 2 (H2)
HGNC id 10027
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a B-chain
  • a connectin C-peptide
  • an A-chain,forming a mature dipeptide (A,B) chains linked by disulfide bond
    • secondary structure
  • two separate polypeptide chains (A-B) that are cross-linked by three disulfide bonds
    • HOMOLOGY
    interspecies ortholog to RLN1
    Homologene
    FAMILY
    CATEGORY signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
    text
  • secreted into the blood
    • basic FUNCTION
  • involved in reproduction (in preterm premature rupture of the membrane)
  • physiological changes leading to parturition
  • may promote the invasive potential of early placental extravillous trophoblasts (EVTs) through up-regulating MMP2, MMP9 mRNAs
  • promoting vasodilatory effects, is a therapy target for the treatment of acute heart failure, and has recently been shown to be highly expressed by cancer cells, aiding in their proliferation, invasiveness and metastasis
  • role for the RLN2 ligand-receptor system at the ocular surface and in the lacrimal apparatus as a potential future therapeutic during wound healing at the ocular surface
  • systemic hormone (sRLN) that is produced by the corpus luteum
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by progesterone receptor (PR)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate carcinoma
    constitutional     --low  
    in diabetes patients
    tumoral     --over  
    of RLN2 and S100A4 might be related to the prediction of metastasis potency and poor prognosis for osteosarcoma patients
    Susceptibility
  • to preterm premature rupture of membranes (PPROM)
  • to spontaneous preterm birth (sPTB)
    • Variant & Polymorphism SNP
  • rs4742076 was associated significantly with PPROM
  • SNP rs3758239 was associated with both PPROM and sPTB
    • Candidate gene
    Marker
  • detection of RLN2 and S100A4 might be useful in evaluating the outcome of patients with osteosarcoma
    • Therapy target
    SystemTypeDisorderPubmed
    cardiovascularaquiredheart failure
    may offer therapeutic advantages in end-stage heart failure
    ANIMAL & CELL MODELS