Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

PON1

contributors: npt/mct - updated : 29-11-2017

HGNC name	paraoxonase 1
HGNC id	9204

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in atherosclerosis constitutional     --low   in patients with calcific aortic valve stenosis (AS) and its activity was inversely correlated with the severity of AS

Susceptibility

to coronary heart disease but not myocardial infarction atherosclerosis pesticide poisoning exsudative age-related macular degeneration to abdominal aortic aneurysm (Giusti 2008) Alzheimer disease (AD) to sporadic amyotrophic lateral sclerosis to attaining longevity to strocke

Variant & Polymorphism SNP , other	Arg192 allele increased survival at extreme advanced age
	polymorphism 192Q/R, 55M/L,and promoter variant 107C/T increases protection against coronary artery disease
	-161[C/T] SNP in creasing the risk of Alzheimer
	Q192R polymorphism increasing the risk of sporadic amyotrophic lateral sclerosis and associated with stroke and myocardial infarction
	variants at codon 192 impact on the probability of attaining longevity
	Q192R polymorphism could be an important risk factor for stroke
	rs854563 associated with coronary atherosclerosis
	multiple variants in PON influence serum paraoxonase activity, and low serum paraoxonase activity is a risk factor for AD

Candidate gene
Marker
Therapy target	for future cardio protection therapy via the macrophage PON1 binding sites

ANIMAL & CELL MODELS