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FLASH GENE
Symbol PLAT contributors: mct - updated : 06-11-2015
HGNC name plasminogen activator, tissue
HGNC id 9051
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
cysteine-rich kringle domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,cytosolic,granule
basic FUNCTION
  • serine protease activating the proenzyme plasminogen to plasmin, which in turn is responsible for fibrinolytic activity
  • implicated in neurite outgrowth and neurological recovery post stroke
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • while SERPINE1 and SERPINB2 function similarly in the control of cellular plasmin generation by PLAT, they may have disparate effects on the alternative functions of PLAT via modulation of its engagement with endocytosis receptors
  • PLAT-SERPINE1 system regulates the senescence-inducing activity of IGFBP3
  • IGFBP3 proteolysis by PLAT resulted in the inactivation of senescence-inducing activity of IGFBP3
  • PLAT influences spatial memory through its preferential interaction with GRIN2D subunit-containing NMDARs
  • binding of PLAT to VDAC1 induced a decrease in K(m) and an increase in the V(max) for activation of its substrate, plasminogen (Pg)
  • converts the zymogen plasminogen (PLG) into plasmin
  • interaction with S100P (S100P C-terminal lysine-dependent activation of tissue plasminogen activator (PLAT), but not of urokinase-catalysed plasminogen activation)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PLAT
    Susceptibility to ischemic stroke
    Variant & Polymorphism other
  • -7351C/T polymorphism in PLAT would be a risk factor for ischemic stroke
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS