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FLASH GENE

Symbol

PLAT

contributors: mct - updated : 06-11-2015

HGNC name	plasminogen activator, tissue
HGNC id	9051

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	PLAT thrombosis, recurrent
Location	8p11.21      Physical location : 42.032.235 - 42.065.194
Synonym name	plasminogen activator, tissue type
	alteplase
	reteplase
Synonym symbol(s)	PLA, TPA
EC.number	3.4.21.68

DNA

TYPE	functioning gene
STRUCTURE	33.01 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

Map	see RP1 RP1

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000930 14 - 3173 NP_000921 - 562 - 1996 8641693 PLAT V2 - - 2160 - 291 - 1996 8641693 NM_033011 13 - 3035 NP_127509 - 516 - 1996 8641693

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Endocrine pancreas       highly Reproductive female system ovary       Respiratory lung         Skin/Tegument skin       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

cysteine-rich kringle domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytosolic,granule

basic FUNCTION	serine protease activating the proenzyme plasminogen to plasmin, which in turn is responsible for fibrinolytic activity
	implicated in neurite outgrowth and neurological recovery post stroke

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

coagulation/hemostasis

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	while SERPINE1 and SERPINB2 function similarly in the control of cellular plasmin generation by PLAT, they may have disparate effects on the alternative functions of PLAT via modulation of its engagement with endocytosis receptors
	PLAT-SERPINE1 system regulates the senescence-inducing activity of IGFBP3
	IGFBP3 proteolysis by PLAT resulted in the inactivation of senescence-inducing activity of IGFBP3
	PLAT influences spatial memory through its preferential interaction with GRIN2D subunit-containing NMDARs
	binding of PLAT to VDAC1 induced a decrease in K(m) and an increase in the V(max) for activation of its substrate, plasminogen (Pg)
	converts the zymogen plasminogen (PLG) into plasmin
	interaction with S100P (S100P C-terminal lysine-dependent activation of tissue plasminogen activator (PLAT), but not of urokinase-catalysed plasminogen activation)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

PLAT

Susceptibility

to ischemic stroke

Variant & Polymorphism other	-7351C/T polymorphism in PLAT would be a risk factor for ischemic stroke

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS