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FLASH GENE
Symbol PDGFA contributors: mct - updated : 19-12-2017
HGNC name platelet-derived growth factor alpha polypeptide
HGNC id 8799
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 20 amino acids signal peptide (2.1 kDa)
  • a 191 amino acids proprotein (21.9 kDa)
  • an 8 cysteine residues
  • a C terminal basic motif
    • mono polymer homomer , heteromer , dimer
    isoforms Precursor a 125 amino acids mature peptide (14.3 kDa)
    HOMOLOGY
    interspecies homolog to rattus Pdgfa (91.19 pc)
    homolog to murine Pdgfa (92.23 pc)
    Homologene
    FAMILY
  • PDGF/VEGF growth factor family
    • CATEGORY signaling cytokine growth factor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • potent mitogen for cells of mesenchymal origin, also involved in transformation process
  • regulating the development of the craniofacial structures
  • induces neovascularization by priming vascular smooth muscle cells /pericytes to release pro-angiogenic mediators (Greenberg 2008)
  • regulates salivary gland morphogenesis via fibroblast growth factor expression (Yamamoto 2008)
  • mesodermal PDGF signaling is not essential in heart development, although its role may be redundant with other signaling pathways (Kang 2008)
  • might be involved in the activation of primordial follicles
  • regulates the interaction of MTSS1L with either wild type or constitutively activated MYC-RAC1 proteins
  • PDGFA signalling might regulate EZH2 expression and age-dependent pancreatic beta-cell proliferation in islets
  • thought to function as a key player in the development and progression of tumor growth by regulating aspects of cell proliferation, angiogenesis and metastasis
  • regulates chondrocyte proliferation through activation of ERK1/2 pathway by upregulation of GIT1 expression and RAC1 phosphorylation
  • PDGFA and TGFB1 regulate acute respiratory distress syndrome (ARDS)-associated lung fibrosis through distinct signaling pathway-mediated activation of fibrosis-related proteins
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    cell-cell signaling
    a component
  • homodimerizing or heterodimerizing with PDGFB
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PDGFRA, PDGFRB
  • CSPG4
  • interacting with KDR and VEGFA
  • PLCG1 is involved with PDGFA in phosphorylation of PEA15
  • by mediating intensive F-actin accumulation at the sites of cell infiltration, WASF2, WASL, and ENAH are crucial for PI3K-dependent cell invasion induced by PDGFA
  • association of MUC1 with PDGFA and MUC1 regulates the expression and secretion of PDGFA
  • activates the proximal 980-bp region of the IL13 promoter
  • RDX, EZR, MSN exert a redundant control on PDGFA-induced vascular smooth muscle cells (VSMC) migration by regulating focal adhesion turn-over and cell adhesion to substrate
  • SOX11 promotes tumor angiogenesis through transcriptional regulation of PDGFA in mantle cell lymphoma
  • SRF regulates craniofacial development through selective recruitment of MKL1 cofactors by PDGFA signaling
  • PDGFA-induced migration of mesenchymal cells requires NOX4 and DUOX1/2 enzymes, which mediate redox-sensitive activation of PI3-kinase pathway and PKB/AKT1
  • PI3CA/AKT2 is a direct PDGFA target that is activated in f adipocyte stem cells (ASCs) during white adipose tissue (WAT) hyperplasia and is functionally required for dermal ASC proliferation
  • PDGFA/PDGFRA signalling as a tissue-autonomous regulator of contact inhibition of locomotion (CIL) by controlling N-cadherin upregulation during epithelial-to-mesenchymal transition (EMT)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    expression of PDGFA and its receptor increased in patients with more serious age-related cataracts
    tumoral       gain of function
    is frequently upregulated in various cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurosensorialvisuallens
    may be a new therapeutic target for cataracts treatment
    respiratorylung 
    treatments with both PDGFA and TGFB1 antagonists may result in a better anti-fibrotic outcome for acute lung injury (ALI)-induced lung fibrosis
    ANIMAL & CELL MODELS