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FLASH GENE

Symbol

PDGFA

contributors: mct - updated : 19-12-2017

HGNC name	platelet-derived growth factor alpha polypeptide
HGNC id	8799

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002607 7 - 2809 NP_002598 24.04 211 - 2014 24703957 encoding for the longer isoform 1 NM_033023 6 splicing 2740 NP_148983 22.2 196 - 2014 24703957 encoding for the shorter isoform 2

EXPRESSION

Rna function	mRNA was expressed in granulosa cells of a minority of the samples from women/girls
Type	widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Digestive esophagus       highly   mouth       lowly Nervous nerve       highly Reproductive female system ovary     moderately Visual eye       lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic       highly

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic platelet Reproductive granulosa cell Homo sapiens Reproductive oocyte Homo sapiens

cell lineage
cell lines
fluid/secretion	secreted

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a 20 amino acids signal peptide (2.1 kDa)
	a 191 amino acids proprotein (21.9 kDa)
	an 8 cysteine residues
	a C terminal basic motif

mono polymer

homomer , heteromer , dimer

isoforms

Precursor

a 125 amino acids mature peptide (14.3 kDa)

HOMOLOGY

interspecies	homolog to rattus Pdgfa (91.19 pc)
	homolog to murine Pdgfa (92.23 pc)

Homologene

FAMILY

PDGF/VEGF growth factor family

CATEGORY

signaling cytokine growth factor

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,lumen
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi

basic FUNCTION	potent mitogen for cells of mesenchymal origin, also involved in transformation process
	regulating the development of the craniofacial structures
	induces neovascularization by priming vascular smooth muscle cells /pericytes to release pro-angiogenic mediators (Greenberg 2008)
	regulates salivary gland morphogenesis via fibroblast growth factor expression (Yamamoto 2008)
	mesodermal PDGF signaling is not essential in heart development, although its role may be redundant with other signaling pathways (Kang 2008)
	might be involved in the activation of primordial follicles
	regulates the interaction of MTSS1L with either wild type or constitutively activated MYC-RAC1 proteins
	PDGFA signalling might regulate EZH2 expression and age-dependent pancreatic beta-cell proliferation in islets
	thought to function as a key player in the development and progression of tumor growth by regulating aspects of cell proliferation, angiogenesis and metastasis
	regulates chondrocyte proliferation through activation of ERK1/2 pathway by upregulation of GIT1 expression and RAC1 phosphorylation
	PDGFA and TGFB1 regulate acute respiratory distress syndrome (ARDS)-associated lung fibrosis through distinct signaling pathway-mediated activation of fibrosis-related proteins

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

cell-cell signaling

a component

homodimerizing or heterodimerizing with PDGFB

INTERACTION

DNA

RNA

small molecule

protein	PDGFRA, PDGFRB
	CSPG4
	interacting with KDR and VEGFA
	PLCG1 is involved with PDGFA in phosphorylation of PEA15
	by mediating intensive F-actin accumulation at the sites of cell infiltration, WASF2, WASL, and ENAH are crucial for PI3K-dependent cell invasion induced by PDGFA
	association of MUC1 with PDGFA and MUC1 regulates the expression and secretion of PDGFA
	activates the proximal 980-bp region of the IL13 promoter
	RDX, EZR, MSN exert a redundant control on PDGFA-induced vascular smooth muscle cells (VSMC) migration by regulating focal adhesion turn-over and cell adhesion to substrate
	SOX11 promotes tumor angiogenesis through transcriptional regulation of PDGFA in mantle cell lymphoma
	SRF regulates craniofacial development through selective recruitment of MKL1 cofactors by PDGFA signaling
	PDGFA-induced migration of mesenchymal cells requires NOX4 and DUOX1/2 enzymes, which mediate redox-sensitive activation of PI3-kinase pathway and PKB/AKT1
	PI3CA/AKT2 is a direct PDGFA target that is activated in f adipocyte stem cells (ASCs) during white adipose tissue (WAT) hyperplasia and is functionally required for dermal ASC proliferation
	PDGFA/PDGFRA signalling as a tissue-autonomous regulator of contact inhibition of locomotion (CIL) by controlling N-cadherin upregulation during epithelial-to-mesenchymal transition (EMT)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   expression of PDGFA and its receptor increased in patients with more serious age-related cataracts tumoral       gain of function is frequently upregulated in various cancers

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurosensorial visual lens may be a new therapeutic target for cataracts treatment respiratory lung   treatments with both PDGFA and TGFB1 antagonists may result in a better anti-fibrotic outcome for acute lung injury (ALI)-induced lung fibrosis

ANIMAL & CELL MODELS