| basic FUNCTION
| active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, |
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and contract (directly or indirectly) many smooth muscles |
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possesses antiapoptotic effects in the colonic mucosa by activating AKT, which prevents apoptosis and mediates tissue recovery during colitis |
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centrally involved in gastric secretion, motility, mucosal immunity, and cell proliferation  |
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playing a role in the regulation of platelet function |
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catabolized by degradative enzymes in tears to maintain the ocular surface by exerting the trophic effects of SP while avoiding undesirable effects |
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multipotent neuropeptide that affects the proliferation, activation and motility of keratinocytes and fibroblasts |
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TAC1/TACR1 system, leads to the activation of nuclear factor-kappa B (NFKB) and proinflammatory cytokines |
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role for TAC1/TACR1 interactions in adipose tissue responses, specifically as they relate to obesity-associated pathologies such as glucose intolerance and insulin resistance |
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upregulated monocyte tissue factor (TF), the major coagulation cascade stimulator, in a concentration and time dependent manner |
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beyond its neuroendocrine and inflammatory effects, could also be involved in targeting adipose tissue and influencing insulin resistance |
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promotes neurite outgrowth and the migration of pancreatic cancer cell cluster to the dorsal root ganglions |
