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FLASH GENE
Symbol ATP6V0C contributors: mct - updated : 08-09-2021
HGNC name ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
HGNC id 855
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1016 - 155 - 2020 31840304
3 - 1093 - 155 - 2020 31840304
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cells
SystemCellPubmedSpeciesStageRna symbol
Skeletonosteoclast
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four hydrophobic membrane-spanning alpha helices
    • HOMOLOGY
    Homologene
    FAMILY V-ATPase family
    CATEGORY enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • ATPase H+ transporting, vacuolar proton pump
  • coupling ATP hydrolysis to proton pumping across membranes
  • plays an important role in programmed cell death
  • is a proton-conducting, pore-forming subunit of vacuolar ATPase, maintains pH homeostasis and induces organelle acidification
  • ATP6V0C enhances likely aerobic glycolysis and motility in esophageal cancer cells (ECCs)
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS electron transport
    text polarization of osteoclats
    PATHWAY
    metabolism energetic
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between RNF182 and ATP6V0C, known for its role in the formation of gap junction complexes and neurotransmitter release channels
  • protects cells against apoptosis through the regulation of HK2 expression
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS