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FLASH GENE
Symbol MOS contributors: mlc - updated : 15-11-2007
HGNC name v-mos Moloney murine sarcoma viral oncogene homolog
HGNC id 7199
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Moloney sarcoma viral (v-mos) oncogene
Homologene
FAMILY Ser/Thr protein kinase family
CATEGORY enzyme , protooncogene
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • cytoplasmic serine/threonine-specific protein kinase with crucial function during meiotic cell division
  • principal meiotic regulator, blocking cells at metaphase II
  • enhancing dephosphorylation of multiple Cdc2 Sites that control FBXO43 stability
    • CELLULAR PROCESS cell cycle,division,meiosis
    PHYSIOLOGICAL PROCESS
    text control of meioses
    PATHWAY
    metabolism
    signaling
    a component
  • component of a large multiprotein complex known as the cytostatic factor (CSF)
    • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP binding
    protein interacting with REC8 (coordinated expression of MOS and REC8 regulate the extent of arrested mitoses and polyploidy)
    cell & other
  • stabilizing the M-phase promoting factor (MPF)
  • activating mitogen-activated protein (MAP) kinase pathway
    • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    aberrantly activated during mitotic catastrophe in TP53 mutated lymphoma cells after irradiation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS