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FLASH GENE

Symbol

MOS

contributors: mlc - updated : 15-11-2007

HGNC name	v-mos Moloney murine sarcoma viral oncogene homolog
HGNC id	7199

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	head to head
STRUCTURE	1.00 kb     1 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 1 - 1041 - 346 - Kalejs (2006)

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Moloney sarcoma viral (v-mos) oncogene

Homologene

FAMILY

Ser/Thr protein kinase family

CATEGORY

enzyme , protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	cytoplasmic serine/threonine-specific protein kinase with crucial function during meiotic cell division
	principal meiotic regulator, blocking cells at metaphase II
	enhancing dephosphorylation of multiple Cdc2 Sites that control FBXO43 stability

CELLULAR PROCESS	cell cycle,division,meiosis

PHYSIOLOGICAL PROCESS

text	control of meioses

PATHWAY

metabolism

signaling

a component

component of a large multiprotein complex known as the cytostatic factor (CSF)

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP binding

protein

interacting with REC8 (coordinated expression of MOS and REC8 regulate the extent of arrested mitoses and polyploidy)

cell & other	stabilizing the M-phase promoting factor (MPF)
	activating mitogen-activated protein (MAP) kinase pathway

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       gain of function aberrantly activated during mitotic catastrophe in TP53 mutated lymphoma cells after irradiation

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS