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FLASH GENE

Symbol

MDH2

contributors: mct - updated : 03-03-2017

HGNC name	malate dehydrogenase 2, NAD (mitochondrial)
HGNC id	6971

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

EIEE51

related resource

MITOP database

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in endometrial carcinoma tissues and related to the grade of the cancer tumoral germinal mutation       in malignant paragangliomas

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     a novel MDH2 inhibitor, compound 7, suppressed HIF1A accumulation via reduction of oxygen consumption and ATP production, integrating metabolism into anti-cancer efficacy in cancer cells

ANIMAL & CELL MODELS