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FLASH GENE

Symbol

LPL

contributors: mct - updated : 26-05-2020

HGNC name	lipoprotein lipase
HGNC id	6677

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

LPL , SBPQ

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     in prostate carcinoma constitutional germinal mutation       associated with the severity of Alzheimer disease pathophysiological features constitutional germinal mutation       in a Chinese infant with severe hypertriglyceridemia constitutional     --low   in the dentate gyrus of Alzheimer's disease brains

Susceptibility

to overweight in post menopausal women to familial combined hyperlipidemia, atherosclerosis, chylomicronaemia, and dyslipidaemia associated with diabetes, insulin resistance, and infection Alzheimer's disease to preeclampsia to coronary heart disease to ischemic heart disease

Variant & Polymorphism SNP

Candidate gene	furin-resistant LPL is a useful reagent for both biochemical and biomedical studies
Marker	LPL expression is the strongest RNA-based prognostic marker in chronic lymphocytic leukemia that could potentially be applied to predict outcome in the clinical setting, particularly in the large group of patients with favorable prognosis
Therapy target

ANIMAL & CELL MODELS