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FLASH GENE

Symbol

AMBP

contributors: - updated : 18-04-2005

HGNC name	alpha-1-microglobulin/bikunin precursor
HGNC id	453

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive liver       highly Lymphoid/Immune spleen

cell lineage
cell lines
fluid/secretion	plasma

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two BPTI/Kunitz inhibitor domains (58AA motif containing three intrachain disulfide bonds) domains

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

lipocalin family Kernel group)

CATEGORY

immunity/defense , transport carrier

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION

inhibition of neurotrophil chemotaxis to endotoxin activated serum

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	expressed in plasma either as a free form or in covalent complexes with albumine IgA and bikunin precursor (ITIL)
	complexing with ITIH1, ITIH2, ITIH3 or ITIH4, to form alpha type inhibitor (respectively inter- and pre-)

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS