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FLASH GENE
Symbol AMBP contributors: - updated : 18-04-2005
HGNC name alpha-1-microglobulin/bikunin precursor
HGNC id 453
DNA
TYPE functioning gene
STRUCTURE 18.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
motif repetitive sequence   ALU
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver   highly
Lymphoid/Immunespleen    
cell lineage
cell lines
fluid/secretion plasma
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two BPTI/Kunitz inhibitor domains (58AA motif containing three intrachain disulfide bonds) domains
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY lipocalin family Kernel group)
    CATEGORY immunity/defense , transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION inhibition of neurotrophil chemotaxis to endotoxin activated serum
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • expressed in plasma either as a free form or in covalent complexes with albumine IgA and bikunin precursor (ITIL)
  • complexing with ITIH1, ITIH2, ITIH3 or ITIH4, to form alpha type inhibitor (respectively inter- and pre-)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS