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FLASH GENE
Symbol WNT2 contributors: npt/mct/pgu - updated : 23-06-2010
HGNC name wingless-type MMTV integration site family member 2
HGNC id 12780
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • cysteine rich domain
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to Drosophila wingless (wg) segment polarity gene
    homolog to int-1 related protein;murine mammary tumor virus integration site (v-int-1) oncogene homolog-like 1
    homolog to murine Wnt2
    Homologene
    FAMILY
  • WNT family
    • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • modulating cell fate and cell behavior during vertebrate development
  • immediate downstream target of GATA-factor regulation during early cardiogenesis
  • functions at multiple stages of development during embryonic stem cell differentiation and during the commitment and diversification of mesoderm
  • autocrine growth and differentiation factor for hepatic sinusoidal endothelial cells
  • activating the beta-catenin /TCF signaling pathway
  • regulator of dopaminergic progenitors and dopaminergic neuron development
  • having a novel function, as a biologically and physiologically relevant player in the regulation of progenitor proliferation and dopaminergic neurogenesis in the developing ventral mesencephalon
  • important role in brain development, and is one of the strong candidate genes for autism
  • acting as an angiogenic growth factor for non-sinusoidal endothelial cells and inhibiting expression of stanniocalcin-1 (STC1)
  • important signaling molecule that promote the earliest aspects of lung airway smooth muscle development
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling signal transduction
    activating the beta-catenin-TCF signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with STC1
  • KDR is a target of WNT2 signaling in hepatic sinusoidal endothelial cells
  • interacts with both FZD3 and FZD9
  • could act through its receptor FZD9 to regulate the CTNNB pathway in cumulus cells, recruiting CTNNB into plasma membranes and promoting the formation of adherens junctions involving CDH1
    • cell & other
    REGULATION
    activated by estrogens in breast cancer
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer
    tumoral     --over  
    might play a role in the development of colorectal cancers, as an early event of carcinogenesis
    Susceptibility to autism
    Variant & Polymorphism other significant association between WNT2 and autism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS