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FLASH GENE

Symbol

WNT2

contributors: npt/mct/pgu - updated : 23-06-2010

HGNC name	wingless-type MMTV integration site family member 2
HGNC id	12780

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Nervous brain diencephalon thalamus     Reproductive female system breast       Respiratory lung

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	in developing allantois, pericardium, ventral lateral mesoderm

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

cysteine rich domain

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to Drosophila wingless (wg) segment polarity gene
	homolog to int-1 related protein;murine mammary tumor virus integration site (v-int-1) oncogene homolog-like 1
	homolog to murine Wnt2

Homologene

FAMILY

WNT family

CATEGORY

protooncogene

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm

basic FUNCTION	modulating cell fate and cell behavior during vertebrate development
	immediate downstream target of GATA-factor regulation during early cardiogenesis
	functions at multiple stages of development during embryonic stem cell differentiation and during the commitment and diversification of mesoderm
	autocrine growth and differentiation factor for hepatic sinusoidal endothelial cells
	activating the beta-catenin /TCF signaling pathway
	regulator of dopaminergic progenitors and dopaminergic neuron development
	having a novel function, as a biologically and physiologically relevant player in the regulation of progenitor proliferation and dopaminergic neurogenesis in the developing ventral mesencephalon
	important role in brain development, and is one of the strong candidate genes for autism
	acting as an angiogenic growth factor for non-sinusoidal endothelial cells and inhibiting expression of stanniocalcin-1 (STC1)
	important signaling molecule that promote the earliest aspects of lung airway smooth muscle development

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

signal transduction

activating the beta-catenin-TCF signaling pathway

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with STC1
	KDR is a target of WNT2 signaling in hepatic sinusoidal endothelial cells
	interacts with both FZD3 and FZD9
	could act through its receptor FZD9 to regulate the CTNNB pathway in cumulus cells, recruiting CTNNB into plasma membranes and promoting the formation of adherens junctions involving CDH1

cell & other

REGULATION

activated by

estrogens in breast cancer

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast cancer tumoral     --over   might play a role in the development of colorectal cancers, as an early event of carcinogenesis

Susceptibility

to autism

Variant & Polymorphism other	significant association between WNT2 and autism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS