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FLASH GENE
Symbol WNT2 contributors: npt/mct/pgu - updated : 23-06-2010
HGNC name wingless-type MMTV integration site family member 2
HGNC id 12780
Location 7q31.2      Physical location : 116.916.687 - 116.963.343
Synonym name
  • secreted growth factor
  • Int-1-related protein
  • protein Wnt-2
  • IRP protein
    • Synonym symbol(s) INT1L1, IRP
    DNA
    TYPE functioning gene
    STRUCTURE 46.66 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2907 - 360 - 2009 19444628
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbraindiencephalonthalamus  
    Reproductivefemale systembreast   
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text in developing allantois, pericardium, ventral lateral mesoderm
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • cysteine rich domain
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to Drosophila wingless (wg) segment polarity gene
    homolog to int-1 related protein;murine mammary tumor virus integration site (v-int-1) oncogene homolog-like 1
    homolog to murine Wnt2
    Homologene
    FAMILY
  • WNT family
    • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • modulating cell fate and cell behavior during vertebrate development
  • immediate downstream target of GATA-factor regulation during early cardiogenesis
  • functions at multiple stages of development during embryonic stem cell differentiation and during the commitment and diversification of mesoderm
  • autocrine growth and differentiation factor for hepatic sinusoidal endothelial cells
  • activating the beta-catenin /TCF signaling pathway
  • regulator of dopaminergic progenitors and dopaminergic neuron development
  • having a novel function, as a biologically and physiologically relevant player in the regulation of progenitor proliferation and dopaminergic neurogenesis in the developing ventral mesencephalon
  • important role in brain development, and is one of the strong candidate genes for autism
  • acting as an angiogenic growth factor for non-sinusoidal endothelial cells and inhibiting expression of stanniocalcin-1 (STC1)
  • important signaling molecule that promote the earliest aspects of lung airway smooth muscle development
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling signal transduction
    activating the beta-catenin-TCF signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with STC1
  • KDR is a target of WNT2 signaling in hepatic sinusoidal endothelial cells
  • interacts with both FZD3 and FZD9
  • could act through its receptor FZD9 to regulate the CTNNB pathway in cumulus cells, recruiting CTNNB into plasma membranes and promoting the formation of adherens junctions involving CDH1
    • cell & other
    REGULATION
    activated by estrogens in breast cancer
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer
    tumoral     --over  
    might play a role in the development of colorectal cancers, as an early event of carcinogenesis
    Susceptibility to autism
    Variant & Polymorphism other significant association between WNT2 and autism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS