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FLASH GENE
Symbol FCN2 contributors: mct/npt - updated : 13/09/2008
HGNC name ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)
HGNC id 3624
PROTEIN
PHYSICAL PROPERTIES globular
STRUCTURE
motifs/domains
  • a leader peptide
  • a short N-terminal segment
  • a collagen-like region
  • a C terminal fibrinogen-like sugar-binding domain
    • conjugated GlycoP
    mono polymer homomer , polymer
    HOMOLOGY
    interspecies homolog to Drosophila CG5550
    intraspecies homolog to FCN1
    Homologene
    FAMILY
  • ficolin (ficolin/opronin p35) lectin family
    • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    text secreted
    basic FUNCTION
  • having an opsonic activity
  • involved in phagocytosis of pathogens
  • soluble oligomeric defence protein with lectin-like activity, assembled from collagen fibers prolonged by fibrinogen-like recognition domains
  • recognizes microbial polysaccharides and glycoconjugates rich in GlcNAc or GalNAc
  • may not be critical for host defence against pneumococcal infection (Chapman 2007)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text antimicrobial humoral response (sensu Invertebrata)
    PATHWAY
    metabolism
    signaling
    a component
  • homopolymer disulfide-linked
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • binding to TGFB1and elastin
    • cell & other
  • binding to carbohydrate
    • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to recurrent respiratory infections
    Variant & Polymorphism SNP , other increasing the risk of recurrent respiratory infections
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS