Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MEST contributors: mct/ - updated : 04-04-2015
HGNC name mesoderm specific transcript homolog (mouse)
HGNC id 7028
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
potential N-linked glycosylation site
HOMOLOGY
interspecies homolog to murine imprinted gene Peg1
Homologene
FAMILY
  • enzyme with significant similarity to alpha/beta hydrolase fold family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • imprinting gene, which is associated with growth of mesodermal origin cells
  • imprinted gene that plays important roles in embryo development
  • novel regulator of Wnt/CTNNB signalling during adipogenic differentiation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with LRP6 (MEST inhibited maturation of LRP6 by controlling the glycosylation of LRP6)
  • SOX6 regulates adipogenesis in vertebrate species by activating adipogenic regulators including PPARG, CEBPA and MEST
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SRS7
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    biallelic expression in cancers
    tumoral     --over  
    in leiomyoma, but without loss of imprinting of the gene
    constitutional     --other  
    hypermethylation was highest in the severe oligozoospermia
    Susceptibility
    Variant & Polymorphism
    Candidate gene Silver-Russel syndrome
    Marker
    Therapy target
    ANIMAL & CELL MODELS