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FLASH GENE

Symbol

MEST

contributors: mct/ - updated : 04-04-2015

HGNC name	mesoderm specific transcript homolog (mouse)
HGNC id	7028

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive esophagus       highly Endocrine pancreas       moderately Nervous nerve       highly Reproductive female system placenta     highly Respiratory lung       moderately Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune lymphocyte

cell lineage	lymphoblastoid cell lines (both isoforms)
cell lines
fluid/secretion

at STAGE

physiological period

pregnancy

Text	hydatidiform mole of androgenetic origin

IMPRINTING	paternally
text	in fetal tissues paternal imprinting and in hydatidiform mole of androgenic origin but expressed from both parental alleles (not imprinted)

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

potential N-linked glycosylation site

HOMOLOGY

interspecies

homolog to murine imprinted gene Peg1

Homologene

FAMILY

enzyme with significant similarity to alpha/beta hydrolase fold family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum

basic FUNCTION	imprinting gene, which is associated with growth of mesodermal origin cells
	imprinted gene that plays important roles in embryo development
	novel regulator of Wnt/CTNNB signalling during adipogenic differentiation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with LRP6 (MEST inhibited maturation of LRP6 by controlling the glycosylation of LRP6)
	SOX6 regulates adipogenesis in vertebrate species by activating adipogenic regulators including PPARG, CEBPA and MEST

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SRS7

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   biallelic expression in cancers tumoral     --over   in leiomyoma, but without loss of imprinting of the gene constitutional     --other   hypermethylation was highest in the severe oligozoospermia

Susceptibility

Variant & Polymorphism

Candidate gene	Silver-Russel syndrome
Marker
Therapy target

ANIMAL & CELL MODELS