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FLASH GENE
Symbol MEST contributors: mct/ - updated : 04-04-2015
HGNC name mesoderm specific transcript homolog (mouse)
HGNC id 7028
DNA
TYPE like-sequence
SPECIAL FEATURE overlapping, gene in gene
text overlapping of MEST 3' utr and exons 21-24 of COPG2
STRUCTURE 20.10 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure
  • transcribed from two promoters, the transcript from promoter P1 is derived from both parental alleles, and the transcript from P2 is exclusively from the paternal allele
  • MAPPING cloned Y linked   status confirmed
    Map cen - D7S530 - NRF1 - UBE2H - CATR1 - CPA2 - CPA1 - MEST - COPG2 - D7S649 - qter
    Authors Hayashida (00)
    RNA
    TRANSCRIPTS type messenger
    text two isoforms : an alternative origin one and one alternative (Kosaki)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2507 - 335 maternally imprinted in normal and carcinoma breast tissue 2000 10631159
    starting from exon 1-2
    12 splicing 2455 - 326 adult lymphocytes, lymphoblastoid cell lines, not imprinted, highly expressed in breast carcinoma 2000 10631159
    starting from exon A skipping exon 1 (A-2)
    - splicing 2400 - - expressed only from the paternal allele, predominantly in testis and in mature motile spermatozoa 2000 10631159
    12 - 2419 - 326 - 2000 10631159
    - - 2471 - 321 - 2000 10631159
    - - 2350 - 292 - 2000 10631159
    - - 2302 - 292 - 2000 10631159
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveesophagus   highly
    Endocrinepancreas   moderately
    Nervousnerve   highly
    Reproductivefemale systemplacenta  highly
    Respiratorylung   moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    cell lineage lymphoblastoid cell lines (both isoforms)
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text hydatidiform mole of androgenetic origin
    IMPRINTING paternally
    text in fetal tissues paternal imprinting and in hydatidiform mole of androgenic origin but expressed from both parental alleles (not imprinted)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    potential N-linked glycosylation site
    HOMOLOGY
    interspecies homolog to murine imprinted gene Peg1
    Homologene
    FAMILY
  • enzyme with significant similarity to alpha/beta hydrolase fold family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • imprinting gene, which is associated with growth of mesodermal origin cells
  • imprinted gene that plays important roles in embryo development
  • novel regulator of Wnt/CTNNB signalling during adipogenic differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with LRP6 (MEST inhibited maturation of LRP6 by controlling the glycosylation of LRP6)
  • SOX6 regulates adipogenesis in vertebrate species by activating adipogenic regulators including PPARG, CEBPA and MEST
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SRS7
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    biallelic expression in cancers
    tumoral     --over  
    in leiomyoma, but without loss of imprinting of the gene
    constitutional     --other  
    hypermethylation was highest in the severe oligozoospermia
    Susceptibility
    Variant & Polymorphism
    Candidate gene Silver-Russel syndrome
    Marker
    Therapy target
    ANIMAL & CELL MODELS