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FLASH GENE

Symbol

LY6H

contributors: npt/ - updated : 26-09-2006

HGNC name	lymphocyte antigen 6 complex, locus H
HGNC id	6728

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	2.41 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

text	variants 2 and 3 encode the same protein

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 950 14.54 140 - Horie (1998) variant 2 - - 1006 16.84 161 - Horie (1998) variant 3 - - 986 16.84 161 - Horie (1998)

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas       lowly Nervous brain forebrain cerebral cortex   highly   brain diencephalon amygdala   highly   brain diencephalon hypothalamus   highly   brain basal nuclei     highly Reproductive male system testis     lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Nervous central

cell lineage
cell lines	acute lymphoblastic leukemia cells and acute human leukemic cell line MOLT-3
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

LY-6 family members of small cysteine-rich proteins

CATEGORY

antigen

SUBCELLULAR LOCALIZATION	plasma membrane
text	attached to the membrane by a GPI-anchor

basic FUNCTION

playing roles in both the central nervous and the immune system

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development , immunity/defense , nervous system

text	histogenesis and organogenesis
	neurogenesis
	cellular defense response

PATHWAY

metabolism

signaling

a component	constituent of lymphocyte antigen complex
	glycosylphosphatidylinositol (GPI)-anchored constituent of cell surface membrane

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS