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FLASH GENE
Symbol DYNC1I1 contributors: mct - updated : 26-11-2016
HGNC name dynein, cytoplasmic, intermediate polypeptide 1
HGNC id 2963
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven WD repeats (TRP-ASP domain)
  • HOMOLOGY
    interspecies homolog to murine Dncic1
    Homologene
    FAMILY dynein intermediate chain family
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,chromatin/chromosome,kinetochore
    basic FUNCTION
  • involved in intracellular movement or organelles and vesicles or in the orientation of the mitotic spindle apparatus
  • directing the dynein molecule to its appropriate subcellular target site
  • DYNC1I1 and DYNC1I2 are involved in dynein cargo binding and dynein complexes with different intermediate chains bind to specific cargoes
  • key role of DYNC1I1 exonic enhancers in normal limb formation
  • DYNC1I1–DYNC1I2 complex formation, the first step of outer dynein arms (ODAs) assembly, does likely not require LRRC6 (
  • CELLULAR PROCESS cell cycle, division
    cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • axonemal constituent of the cytoplasmic dynein made of two heavy and several light and intermediate chains
  • INTERACTION
    DNA
    RNA
    small molecule
    protein binding directly to eIF3k (PLAC-24)
    cell & other
  • microtubules binding
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS