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FLASH GENE
Symbol DYNC1I1 contributors: mct - updated : 26-11-2016
HGNC name dynein, cytoplasmic, intermediate polypeptide 1
HGNC id 2963
Location 7q21.3      Physical location : 95.401.817 - 95.727.735
Synonym symbol(s) DNCIC1, DYI1, DNCI1, IC1
DNA
TYPE functioning gene
STRUCTURE 337.82 kb     17 Exon(s)
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 2337 - 602 - 2013 23960070
17 - 3061 - 645 - 2013 23960070
16 - 3001 - 625 - 2013 23960070
17 - 3010 - 628 - 2013 23960070
16 - 2950 - 608 - 2013 23960070
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text developing forebrain,peripherous nervous system
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven WD repeats (TRP-ASP domain)
  • HOMOLOGY
    interspecies homolog to murine Dncic1
    Homologene
    FAMILY dynein intermediate chain family
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,chromatin/chromosome,kinetochore
    basic FUNCTION
  • involved in intracellular movement or organelles and vesicles or in the orientation of the mitotic spindle apparatus
  • directing the dynein molecule to its appropriate subcellular target site
  • DYNC1I1 and DYNC1I2 are involved in dynein cargo binding and dynein complexes with different intermediate chains bind to specific cargoes
  • key role of DYNC1I1 exonic enhancers in normal limb formation
  • DYNC1I1–DYNC1I2 complex formation, the first step of outer dynein arms (ODAs) assembly, does likely not require LRRC6 (
  • CELLULAR PROCESS cell cycle, division
    cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • axonemal constituent of the cytoplasmic dynein made of two heavy and several light and intermediate chains
  • INTERACTION
    DNA
    RNA
    small molecule
    protein binding directly to eIF3k (PLAC-24)
    cell & other
  • microtubules binding
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS