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FLASH GENE
Symbol ELAVL2 contributors: - updated : 05-04-2006
HGNC name ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
HGNC id 3313
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three copies of the RNP motif, binding to AU-rich elements (ARE), of early response-gene messenger
  • a HNS signal (HUR nuclear cytoplasmic shuttling sequence)
    • HOMOLOGY
    intraspecies homolog to HEL-N1
    Homologene
    FAMILY ELAV rnp proteins family
    CATEGORY regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • shuttling the ERG class of mRNA to the cytoplasm in response to regulatory signals, where they become stabilized, translated or rapidly degraded, required for normal neuronal development in the embryonic CNS
  • implicated in the control of stabilization, nuclear export, and/or translation of specific mRNAs with AU-rich elements (AREs) in the 3'-untranslated region
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA RNA binding protein
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS