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FLASH GENE

Symbol

ELAVL2

contributors: - updated : 05-04-2006

HGNC name	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
HGNC id	3313

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pharynx         Nervous brain         Reproductive female system ovary         male system testis

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	three copies of the RNP motif, binding to AU-rich elements (ARE), of early response-gene messenger
	a HNS signal (HUR nuclear cytoplasmic shuttling sequence)

HOMOLOGY

intraspecies

homolog to HEL-N1

Homologene

FAMILY

ELAV rnp proteins family

CATEGORY

regulatory , RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	shuttling the ERG class of mRNA to the cytoplasm in response to regulatory signals, where they become stabilized, translated or rapidly degraded, required for normal neuronal development in the embryonic CNS
	implicated in the control of stabilization, nuclear export, and/or translation of specific mRNAs with AU-rich elements (AREs) in the 3'-untranslated region

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA	RNA binding protein

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS