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FLASH GENE

Symbol

CAMK2B

contributors: shn/npt/pgu - updated : 28-12-2017

HGNC name	calcium/calmodulin-dependent protein kinase II beta
HGNC id	1461

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain hindbrain cerebellum   highly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	fetal brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a catalytic domain
	a regulatory region composed of an autoinhibitory domain
	a calmodulin-binding domain
	an ATP-binding site
	autophosphorylation sites

HOMOLOGY

interspecies	ortholog to Camk2b, Mus musculus
	ortholog to Camk2b, Rattus norvegicus
	ortholog to camk2b1, Danio rerio

Homologene

FAMILY	serine/threonine protein kinase family
	Ca(2+)/calmodulin-dependent protein kinase subfamily

CATEGORY

enzyme , receptor membrane serine/threonine kinase

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic,vesicle
	intracellular,nucleus,nucleoplasm
text	insulin secretion vesicles

basic FUNCTION	serine/threonine protein kinase, calcium/calmodulin dependent, controling insulin secretion
	having important actions on proteins regulating cardiac excitation-contraction coupling
	involved in synaptic plasticity in the brain, playing a dual role in excitatory synaptic plasticity: a signaling role during neuronal activity, and an actin-bundling role during the basal state in dendritic spines, thereby affecting both functional and structural plasticity of dendritic spines
	phosphorylates MAP2, increasing its binding to microtubules
	required for dendritic growth and branching
	its activity regulates the proliferative potential of growth plate chondrocytes
	CAMK2A, CAMK2B act in concert, but with distinct functions, to regulate hippocampal synaptic plasticity and learning
	specifically activates IL10 promoter activity
	distinct role in the induction of anergy in T lymphocytes, by differential regulation of IL10 and IL2 gene transcription suggesting MEF2A as a molecular target which can integrate different calcium signals
	is critical for the proper morphological maturation of differentiating oligodendrocytes, an aspect of oligodendrocyte maturation that is mediated to a large extent by changes in the cellular cytoskeleton
	critical role of CAMK2B in regulating oligodendrocyte maturation and CNS myelination via an actin-cytoskeleton-regulatory mechanism
	. CAMK2A, CAMK2B are essential for various forms of synaptic plasticity
	crucial role of CAMK2B in regulating CNS myelination, suggesting that a sodium-dependent glutamate transporter-CAMK2B-actin cytoskeleton axis plays an important role in the regulation of oligodendrocyte maturation and CNS myelination
	molecular, temporal and region-specific role of CAMK2B in locomotion

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

text	growth control proliferation

PATHWAY

metabolism

carbohydrate

signaling

a component

cytoskeletal component in the postsynaptic structure

INTERACTION

DNA

RNA

small molecule

protein	calcium/calmodulin-dependent protein kinase II inhibitor 2 (CAMK2N2)
	leucine rich repeat containing 7 (LRRC7 also known as Densin-180)
	CAMK2B robustly phosphorylates the intracellular domain of NLGN1
	CAMK2B protects neurons from Homocysteine-induced apoptosis with the involvement of HIF1A signal pathway
	PLAA is located in caveolae, where it interacts with PDIA3 and CAV1 to initiate rapid signaling via CAMK2A, CAMK2B

cell & other

REGULATION

repressed by

WNT signaling and PTHLH-induced phosphatase activity which negatively regulate CAMK2 activity

ASSOCIATED DISORDERS

corresponding disease(s)

MRD54

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in cardiomyopathy

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Camk2b(-/-) mice, which lack the beta isoform of Calcium/Calmodulin-dependent protein kinase 2 (CAMK2B), show very severe locomotion deficits