Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

TFPI2

contributors: mct - updated : 23-12-2014

HGNC name	tissue factor pathway inhibitor 2
HGNC id	11761

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   silencing by methylation in esophageal squamous cell carcinoma tumoral     --low   by promoter hypermethylation in nasopharyngeal carcinoma

Susceptibility

Variant & Polymorphism other	Identification of a human TFPI-2 splice variant that is upregulated in human tumor tissues

Candidate gene
Marker	may be a useful diagnostic marker for the aggressive phenotype of glial tumors
	detection of TFPI2 methylation in stool DNA may act as a useful adjunct to the noninvasive strategies for screening of colorectal cancer
Therapy target
	System Type Disorder Pubmed cancer digestive oesophagus potentially important therapeutic role for recombinant TFPI2 in the treatment of malignant esophageal carcinomas

ANIMAL & CELL MODELS